Transport of macrocyclic compounds across phospholipid bilayers by umbrella-rotaxanes.
نویسندگان
چکیده
We report the synthesis and assembly of umbrella-rotaxanes with transmembrane transport properties. We describe their amphomorphism and validate their ability to penetrate and cross phospholipid bilayers. Furthermore we present the strategy to release the macrocyclic compound by enzymatic cleavage inside egg yolk phosphatidylcholine (EYPC) liposomes.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 36 شماره
صفحات -
تاریخ انتشار 2013